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27 In the pancreas, GLP-1 receptor (GLP-1R) activation in islet cells promotes glucose-dependent insulin secretion from -cells, 28 inhibits glucagon release from -cells, and suppresses exocrine function via induction of pancreatic somatostatin

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A case series published in PMC and a 2024 analysis by Neeland, Linge, and Birkenfeld in Diabetes, Obesity and Metabolism both support structured resistance training as the lever for lean tissue preservation during GLP-1 treatment

However, initial changes in appetite and eating patterns are essential to laying the foundation for sustainable results over time

Thus, the risks for these complications underscore the importance of understanding what mechanisms drive the success of surgery so that other, simpler strategies can be applied or so that we can determine which patients will respond most optimally to surgery

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