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=It is speculated that semaglutide (or associated rapid metabolic/vascular changes) may affect optic nerve head perfusion (blood flow) or affect vascular risk in susceptible individuals
The agency has drawn a hard line
The SELECT trial is one of the largest cardiovascular outcome trials of its kind, involving over 17,600 participants with established cardiovascular disease who were overweight or obese but did not have diabetes (2 Trusted Source Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial Go to source)
Berberine has glucose-modulating properties that may complement tirzepatide effects on blood sugar regulation and appetite
[DOI] [PMC free article] [PubMed] [Google Scholar] 194.Kato S, Maruyama S, Makino H, et al
