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Semaglutide carries a boxed warning for medullary thyroid carcinoma risk in personal or family history

Statins (HMG-CoA Reductase Inhibitors) Examples: Atorvastatin Simvastatin Rosuvastatin Pravastatin Lovastatin Mechanism: Inhibit HMG-CoA reductase cholesterol synthesis LDL receptors LDL Effects: LDL (major) Mild TG Mild HDL Side Effects: Myopathy / Rhabdomyolysis Hepatotoxicity ( LFTs) Contraindicated in pregnancy Notes: First-line for hypercholesterolemia Take at night (short-acting statins) 2

Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, Lau DCW, le Roux CW, Violante Ortiz R, Jensen CB, Wilding JPH

Large clinical trials including LEADER, SUSTAIN-6, and EXSCEL have not identified increased fracture rates with GLP-1 therapy compared to placebo

Assuming rebates of 50% across all GLP-1 products in 2024 would mean net spending of around $14 billion in 2024

By mimicking a natural hormone that reduces appetite, Semaglutide lowers after-meal blood sugar spikes and increases fat burning- all of which can jumpstart weight loss when combined with a healthier diet