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Moderate doses within recommended dietary allowances are generally safe, but excessive supplementation is unnecessary

The Semaglutide Treatment Effect in People with Obesity and Heart Failure with Preserved Ejection Fraction and Diabetes Mellitus (STEP-HFpEF DM) trial demonstrated that semaglutide significantly reduced body weight and improved HF-related symptoms and physical limitations in people with obesity-related HF with preserved ejection fraction and type 2 diabetes mellitus [93]

Evidence suggests potential benefits for reproductive hormones in conditions like polycystic ovary syndrome (PCOS), though most hormonal effects appear secondary to metabolic improvements rather than direct hormonal modulation

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The jawline loses its crisp definition as supporting fat diminishes

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