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A cardiac magnetic resonance substudy of the SUMMIT trial showed that tirzepatide treatment led to a placebo-corrected reduction of left ventricular mass by 11 g ([95% CI 419 g]

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Liraglutide (LEADER trial) and injectable semaglutide (SUSTAIN-6) showed significant MACE reduction, but CV benefit does not appear to be a class effect

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Peptides sit somewhere between small-molecules and biosimilars in this regard

GLP-1 receptor agonists slow gastric emptying, meaning food remains in the stomach longer before moving into the small intestine