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Future large-scale randomized trials across diverse populations are warranted to confirm these benefits, clarify optimal dosing and treatment duration, and elucidate mechanisms underlying risk reduction, particularly in understudied subgroups

Metformin must be used cautiously in patients with kidney disease (estimated glomerular filtration rate below 30 mL/min/1.73m), though semaglutide itself does not require dose adjustment for renal impairment

Enhanced Energy and Quality of Life: Many patients report feeling more energetic, motivated, and confident as their health improves

For example, in the SUSTAIN-11 trial, semaglutide showed better glycemic control and weight loss outcomes compared to insulin aspart [12]

Naltrexone was originally developed to treat opioid and alcohol dependence

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