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They are not a cure

WOMAC pain scores were reduced by up to 4.5 points a 75.8% reduction and more than one in eight retatrutide-treated patients were completely free of knee pain at trial end

By this point, 73% of participants had achieved at least 15% total weight loss

While they provide a mechanistic framework for identifying high-potential drugs based on their interactions within disease-associated networks, they do not replace direct clinical validation