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Randomised clinical programmes and the SUMMIT outcomes trial have demonstrated symptomatic and functional improvements, reverse cardiac remodelling on imaging, reduced circulating markers of myocardial stress and fewer worsening heartfailure events versus placebo, alongside signals of renal stabilisation

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Never freeze the solution, and minimize the time spent at room temperature

Participants given the highest dose lost around 20 pounds in 12 weeks, and others lost inches from their waist in 6 months

If you see particulates, cloudiness, or discoloration other than pink, do not use the vial

Even over-the-counter decongestants containing pseudoephedrine can temporarily spike appetite and interfere with the medication's appetite-suppression benefit