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Prevention by metformin

This works synergistically with retatrutide's mechanism to prolong feelings of fullness

Bridgewater, NJ: Sanofi-aventis U.S.;2019
GLP-1 drugs have been shown to be effective for weight loss, though they come with a number of side effects for some patients, including nausea, vomiting, headaches, diarrhea, and constipation, according to Harvard Medical School and the Cleveland Clinic

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Individuals with a personal or family history of Medullary Thyroid Cancer or Multiple Endocrine Neoplasia Type 2 (MEN 2) should not take a GLP-1 agonist
