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Additionally, combination of SGLT-2 inhibitors with finerenone leads to greater reduction of albuminuria [41] and triple therapy with the addition of a GLP-1 receptor agonist may offer even more pronounced cardiovascular risk reductions [21]

Such studies should incorporate systematic assessment of total, bioavailable, and free testosterone levels, as well as estradiol, during pharmacologically induced weight loss in order to clarify whether normalization of the endocrine milieu mitigates lean mass decline

Psychological shift: This is when people start believing the medication actually works

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GLP-1 receptor agonists for weight reduction in people living with obesity