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The G-Protein Coupled Receptor GPR40 Directly Mediates Long-Chain Fatty Acid Induced Secretion of Cholecystokinin

Heres how its different from previous meds: Retatrutide is a triple agonist, meaning it targets three different hormone receptors, rather than one (like Ozempic) or two (like Mounjaro or Zepbound)

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Additionally, PC1/3 is expressed in -cells but at lower levels than PC2, and the ratio of GLP-1 to glucagon expressed in islet cells has been shown to be increased during the progression of diabetes (OMalley et al., 2014)

Risk factors: type 1 or type 2 diabetes, concurrent SGLT2 inhibitor use, prolonged fasting or illness while on keto, very strict carbohydrate restriction below 20 grams during acute illness