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Microglia mediate host defense against infectious pathogens, harmful self-proteins such as A, aggregated -synuclein, mutant or oxidized superoxide dismutase, mutant huntingtin or prions, as well as primary or metastatic CNS tumors (Hickman et al., 2018)
Others may need medications
However, clinicians prioritise symptom-based assessment rather than theoretical risk
Randomized clinical trials and meta-analytic data consistently demonstrate that testosterone therapy increases lean body mass in men with low testosterone concentrations [15,16,19]
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The study cited cost and side effects as reasons for their discontinuation
