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In clinical trials, retatrutide has shown weight loss exceeding 24% of body weight, surpassing both semaglutide and tirzepatide

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doi: 10.1016/S0140-6736(09)61375-1 11 AthaudaD.FoltynieT

Research indicates that the activation of GLP-1R can alter the polarization of microglia, shifting them from a proinflammatory (M1) phenotype to an anti-inflammatory (M2) phenotype (Qian et al., 2022)

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