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Motixafortide and G-CSF to mobilize hematopoietic stem cells for autologous transplantation in multiple myeloma: a randomized phase 3 trial

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Cannabinoid receptor 1 (CB1R) is expressed in presynaptic and postsynaptic neuronal sites in the lateral habenula, where they modulate behavioral responses to stress exposure, such that CB1R blockade reduced anxiety-like behaviors [50] and also in GABAergic cells in the ventral tegmental area (VTA) and their stimulation increases firing of dopamine neurons, which modulate reward [51]

Effective HbA1c reduction with low hypoglycemia risk Clinically meaningful weight loss Proven cardiovascular benefits in high-risk patients Compared to traditional therapies like insulin or sulfonylureas, this represents a significant shift in treatment priorities

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The rate of hypoglycaemia was also not significantly different when compared with the placebo