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The Effectiveness of Semaglutide for Weight Loss In multiple large clinical trials with thousands of participants, semaglutide 2.4 mg led to substantial weight reduction: In a 68-week study of nearly 2000 adults, those getting semaglutide injections lost 14.9% body weight on average compared to 2.4% with placebo plus lifestyle intervention

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Back to Journals Diabetes, Metabolic Syndrome and Obesity Volume 18 Relative Effectiveness and Safety of the GLP-1 (Glucagon-Like Peptide 1) Receptor Agonists, Semaglutide and Liraglutide in the Treatment of Obese Type 2 Diabetics: A Prospective Observational Cohort Study in Poland Authors Hoffmann K, Michalak M , Paczkowska A Received 1 April 2025 Accepted for publication 1 July 2025 Published 7 August 2025 Volume 2025:18 Pages 27232738 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Halis Akturk Karolina Hoffmann, 1 Micha Michalak, 2 Anna Paczkowska 3 1 Department and Clinic of Internal Diseases and Metabolic Disorders, Poznan University of Medical Sciences, Pozna, Poland