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That means: Your body also develops a tolerance to the GI side effects over time, which is why patients who start carefully can tolerate higher doses later in treatment that would have been overwhelming at week one

S., McCaffery J

Semaglutide, the active ingredient in drugs like Wegovy and Ozempic, is also effective at reducing symptoms of heart failure, new research shows
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Conference on Retroviruses and Opportunistic Infections, San Francisco, abstract 113, 2025
