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Kidney injury: Dehydration and vomiting caused by gastrointestinal side effects of retatrutide can lead to kidney injury

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Tirzepatide has a different side effect profile, and many people who struggled with semaglutide find tirzepatide more tolerable, though the reverse can also be true

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PMID: 32985256 Gerontology Activation of the Vascular Smooth Muscle GLP-1/NCX1 Pathway Regulates Cytoplasmic Ca2+ Homeostasis and Improves Blood Pressure Variability in Hypertension

For patients deciding between semaglutide and tirzepatide or between weekly injection and daily ODT genetic insight can add another layer of personalization