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By the late 1990s, the pieces were in place: GLP-1 was a validated target , and prototype therapeutic agents (exendin-4 and a few modified human GLP-1 analogs) were entering clinical testing

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GLP-1R and GIPR dual agonist I-M-150847 shows a distinct temporal and spatial signaling and trafficking pattern To assess the signaling efficiency in a physiological milieu, we carried out a comparative analysis of I-M-150847 with liraglutide in BRIN-BD11 pancreatic beta cells that express both the receptors (Fig 2 supplementary Fig 1)