glp-1 receptor agonist kidney outcomes semaglutide flow trial 2024 results Comparative renal of matched cohorts of patients with type 2 diabetes receiving SGLT2 inhibitors or agonists under routine care | Diabetologia The rationale, design and baseline

doi: 10.1111/dom.16316

T2DM patients have much higher SGLT2 expression in their kidneys than do healthy individuals

Zhang XP, Hintze TH

Body weight decreased dose-dependently (Fig

Key Points Native human GLP-1 normalizes hyperglycaemia in patients with type 2 diabetes mellitus, but the short in vivo half-life of this hormone limits its therapeutic application A number of synthetic GLP-1 receptor agonists, with half-lives between 23 h and several days, have been developed for the long-term treatment of type 2 diabetes mellitus Short-acting GLP-1 receptor agonists (such as exenatide and lixisenatide) predominantly lower postprandial glucose levels and insulin concentrations via retardation of gastric emptying Long-acting GLP-1 receptor agonists (such as albiglutide, dulaglutide, exenatide long-acting release and liraglutide) predominantly lower blood glucose levels through stimulation of insulin secretion and reduction of glucagon levels Adverse effects of GLP-1 receptor agonists include nausea, vomiting and diarrhoea, injection-site reactions, antibody formation and increased heart rate This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access 176,64 per year only 14,72 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

Baseline Demographics and Medication Profiles A total of 125 youth were included (median age 14.83 years), with 113 on metformin and 12 on GLP-1RA therapy