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In a phase 2, double-blind, placebo-controlled trial of retatrutide vs placebo (NCT04881760), adults with obesity or with overweight and obesity-related complications but without diabetes who were treated with retatrutide achieved a mean weight reduction of up to 17.5 % at 24 weeks (primary endpoint) and up to 24.2 % at 48 weeks in the 12 mg group

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Those same mechanisms drive side effects that need monitoring

This model may offer deeper clinical context if the prescriber knows the patient's full medical history

However, this should be tailored to the specific peptide sequence

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