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A stratified analysis demonstrated this association was increasingly prominent in older age groups

In rodent studies, GLP-1 medications caused thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)

Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the glucagon-like peptide 1 (GLP-1) receptor agonist exenatide twice daily or other glucose-lowering therapies: a retrospective analysis of the LifeLink database

UK SmPCs note that in rodent studies, some GLP-1 agonists caused thyroid C-cell tumours, though the clinical relevance in humans is unknown

Dose-related increases in heart rate have been observed, peaking around 24 weeks before declining

[DOI] [PubMed] [Google Scholar] 113.Basolo A., Heinitz S., Stinson E.J., Begaye B., Hohenadel M., Piaggi P., Krakoff J., Votruba S.B