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GLP-1RA can help maintain a balance of energy metabolism in cardiomyocytes through activating PI3K/Akt as well as p38 MAPK pathways as well as activating Nrf-2/heme oxygenase-1 (HO-1), contributing to augmented adenosine triphosphate formation and glucose ingestion by cardiomyocytes [153-155]

[2] [7] These findings led regulatory authorities, including the Medicines and Healthcare products Regulatory Agency (MHRA) and the European Medicines Agency (EMA), to include specific warnings and precautions in the prescribing information for all GLP-1 medications

EB gave substantial contribution to drafting the article or revising it critically for important intellectual content and final approval of the version to be published

doi: 10.1038/nrendo.2015.216

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For patients with concurrent diabetes or obesity , discuss whether GLP-1 therapy is appropriate based on established indications