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Do glucagon-like peptide1 (GLP1) receptor agonists cause musculoskeletal symptoms such as body aches, joint pain, and stiffness?

GLP-1RA can reduce MACE (major cardiovascular events) and its individual components, CV death, myocardial infarction (MI) and stroke

doi: 10.3389/fphys.2022.983961 Received 01 July 2022 Accepted 07 September 2022 Published 20 September 2022 Volume 13 - 2022 Edited by Claudio de Lucia, Scientific Clinical Institute Maugeri (ICS Maugeri), Italy Reviewed by Oscar Lorenzo, Health Research Institute Foundacion Jimenez Diaz (IIS-FJD), Spain Raffaele Carraro, La Princesa University Hospital, Spain Updates Copyright 2022 Kreiner, Hovingh and von Scholten

Notably, the PNA model mimics a lean phenotype with subtle metabolic alterations and may phenocopy the human phenotype B of PCOS 45 , characterized by hyperandrogenism and oligo-anovulation, with cycle irregularities

In studies on cardiovascular diseases, GLP-1RAs have shown potential benefits

Safadi R, Konikoff FM, Mahamid M et al (2014) The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease