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Microbial metabolites and brain signaling Beyond GLP-1 itself, the metabolites produced by the three Pendulum strains have independent effects on brain-gut communication

Newer agents, notably semaglutide and tirzepatide, offer very potent, long-acting effects on weight loss

Nat Immunol (2010) 11:37384

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In contrast, control mice with matching weight loss were not protected from atherosclerosis, suggesting that liraglutide has anti-atherogenic effects independent of weight loss

Owen, R