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10.2147/IJN.S413515 [DOI] [PMC free article] [PubMed] [Google Scholar] 197.Maiseyeu A, et al

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demonstrated that the GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant Apoe/Irs2+/ mice by promoting macrophage polarization towards an anti-inflammatory M2 phenotype, which was associated with enhanced plaque stability (i.e., thicker fibrous caps, fewer necrotic cores, and decreased inflammatory infiltrates)

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In the study, the authors report that of the 8,803 patients who took Wegovy in the trial, 569 (6.5%) had a heart attack or another cardiovascular event, compared with 701 of the 8801 patients (8.0%) in the placebo group