maintenance on glp 1 GLP-1 is harder : r/GLPGrad Long Term GLP-1 Use: Maintenance
Description
Both tirzepatide and certain GLP-1 receptor agonists show some degree of this pattern for gastric emptying after repeated doses

The appetite suppression these drugs create makes it difficult to eat enough protein to preserve muscle mass, and roughly 25% of weight lost on GLP-1 drugs comes from lean tissue on average, with some trials reporting up to 40%

GZR18, a novel long-acting GLP-1 analog, demonstrated positive in vitro and in vivo pharmacokinetic and pharmacodynamic characteristics in animal models

As interest grows, so does the question do glp 1 patches work as effectively as injectable therapy

A total of 145 participants (33.1% with type 2 diabetes) were randomly assigned to once weekly efinopegdutide 10 mg or semaglutide 1 mg following dose titration

At 150 lb (68 kg): 80 g, 95 g, 110 g
