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For new patients, healthcare providers typically start with a low dose and gradually increase the dose over time to help with side effects until an effective maintenance dose is reached

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However, skin sensitivity can have many possible causes, including irritation, changes in hydration, vitamin levels, nerve sensitivity, viral infections, stress or unrelated skin conditions

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Reduced blood flow to genital tissues decreases natural lubrication and overall sensation, making penetrative sex uncomfortable and reducing the arousal response that normally precedes and accompanies it