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Efficacy and safety of short- and long-acting glucagon-like peptide 1 receptor agonists on a background of basal insulin in type 2 diabetes: a meta-analysis

Furthermore, there is a lack of randomized controlled trials, standardized outcome measures, and long-term follow-up reports

Among them, genetically proxied GCGR/GLP-1R agonists showed a causal effect on reduced risk of CVD (OR: 0.78, 95%CI: 0.740.81, P = 8.50 10 26 ), and the GLP-1R agonist was observed to be causally associated with heart failure (OR: 0.21, 95%CI: 0.070.61, P = 4.04 10 3 ) (Supplementary Table 5)

Research continues to show the effectiveness of semaglutide injections for weight loss

To minimize the risks of bone and muscle loss, experts recommended focusing on both protein intake and strength training

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