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Several guidelines currently recommend GLP-1 RAs as add-on therapy to almost all diabetic treatments (with the exception of dipeptidyl peptidase-4 [DPP-4] inhibitors) and even as monotherapy to those intolerant to metformin

( 10.1007/s00125-017-4450-9) [DOI] [PubMed] [Google Scholar] Kahles F, Liberman A, Halim C, Rau M, Mollmann J, Mertens RW, Ruckbeil M, Diepolder I, Walla B, Diebold S, et al

All data collected at the planned end of treatment (week 52), irrespective of discontinuation of the trial product or initiation of rescue medication, were included in the statistical analysis

After all, thats why 65% of people give up on their diet

Carhill AA, Cabanillas ME, Jimenez C, Waguespack SG, Habra MA, Hu M, Ying A, Vassilopoulou-Sellin R, Gagel RF, Sherman SI, Busaidy NL

Early clinical trials in the 2010s demonstrated that semaglutide outperformed existing diabetes medications by improving both glycemic control and body weight