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Table 3 Results of a 52-week Monotherapy Trial in Adults with Type 2 Diabetes Mellitus a Figure 3 Mean HbA 1c for Adult Patients with Type 2 Diabetes Mellitus who Completed the 52-week Trial and for the Last Observation Carried Forward (LOCF, intent-to-treat) data at Week 52 (Monotherapy) Combination Therapy Add-on to Metformin In this 26-week trial, 1,091 adult patients with type 2 diabetes mellitus were randomized to liraglutide injection 0.6 mg, liraglutide injection 1.2 mg, liraglutide injection 1.8 mg, placebo, or glimepiride 4 mg (one-half of the maximal approved dose in the United States), all as add-on to metformin

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However, emerging evidence suggests that stopping therapy often leads to weight regain, reinforcing the concept of obesity as a chronic condition requiring ongoing pharmacologic support

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