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Zepbound is also approved for moderate-to-severe obstructive sleep apnea in individuals with obesity

Interestingly, the GLP-1R/GLP-2R dual agonist dapiglutide is being investigated in the DREAM Trial (NCT05788601) to lower body weight and low-grade inflammation in obesity

Deficiency can cause nerve pain and heightened sensitivity

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Sci Rep 15 , 32385 (2025)

While there has been no clear association with certain psychiatric side effects, such as depression or suicidal ideation in research-based 31 or real-world 32 samples, the potential modulation of reward pathways by these drugs necessitates vigilant monitoring in patients with psychiatric histories, particularly in the setting of treatment with a medication that can substantially modulate the response of appetitive neurocircuitry to natural rewards such as food and water