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However, semaglutide therapy is also associated with concerning adverse effects like acute pancreatitis, anesthetic risks like pulmonary aspiration or residual gastric content, acute kidney injury, acute gallbladder injury, nonarteritic anterior ischemic optic neuropathy and diabetic retinopathy

United States Pharmacopeia guidelines typically recommend a maximum 28-day beyond-use date for multi-dose vials stored under refrigeration, even if chemical stability data suggests longer viability

Patients often see initial results within a few weeks , with more significant weight loss over several months

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