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One longer-term study followed people taking semaglutide for 208 weeks (about 4 years)

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Common (affecting one in 10100 people): Decreased appetite, vomiting, constipation, abdominal pain, dyspepsia, abdominal distention, eructation, flatulence, gastro-oesophageal reflux disease, hypoglycaemia when used with metformin plus an SGLT2 inhibitor, increased heart rate, increased lipase, increased amylase, hypersensitivity reactions, fatigue and injection site reactions

Lilly Trial Connect: provides sponsor information for clinical trial searches

The authors found that GLP-1 RA use was associated with a significantly decreased risk of developing dry AMD compared with patients taking metformin (HR = .68), insulin (HR = .72), and statins (HR = .70)