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Nausea is one of the most common side effects when starting semaglutide therapy, but it's usually temporary

At study entry, 38% of the patients were taking sodium glucose cotransporter 2 (SGLT2) inhibitors or glucagon-like peptide-1 receptor agonists (GLP-1 RAs), medications for diabetes that have been shown to have beneficial effects on heart disease, including reducing heart failure, heart attacks and strokes

If you notice your poop is black, it might be due to diet, medication, or a medical problem

However, this is an average from studies, and your timeline will depend on a combination of factors, including your starting weight, dosage, and commitment to lifestyle changes.