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Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsBlood Glucose Lowering AgentsDrugs Used in DiabetesGastrointestinal HormonesGLP-1 Agonists Approval status Approved drug, Investigational drug Top origins China, India, United States, Singapore, Taiwan Primary indications Semaglutide is always intended to be used with a reduced calorie diet and increased physical activity It is indicated to improve glycemic control in adults diagnosed with type 2 diabetes mellitus However, semaglutide is not a suitable first-line drug for diabetes that has not been controlled by diet and exercise In addition, it has not been studied in patients with pancreatitis Product Snapshot Semaglutide is available as a subcutaneous injectable peptide and as an oral smallmolecule formulation It is used for glycemic control in type 2 diabetes and for chronic weight management in obese or overweight populations It is approved in the US, Canada, and the EU, with some uses remaining investigational Clinical Overview Semaglutide (CAS 910463-68-2) is a longacting glucagonlike peptide1 receptor agonist indicated for improving glycemic control in adults with type 2 diabetes as an adjunct to diet and exercise

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