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Introduction Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are key therapies for type 2 diabetes and obesity, regulating blood glucose by mimicking endogenous GLP-1

By combining data from observational and Mendelian randomization (MR) studies, we aimed to investigate whether GLP-1 RAs decrease the risk of DR

Methods Databases were searched for randomized controlled trials (RCTs), casecontrol, cohort and observational studies involving use of GLP1RA in the intervention arm post-bariatric surgery

When combined with a balanced diet and exercise, it may support healthy weight management and overall wellbeing

Therefore, it demonstrates significant efficacy in weight loss, blood sugar control, and cardiovascular protection, making it an important treatment option for type 2 diabetes patients and individuals managing their weight