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Medical supervision allows real-time changes to your treatment plan whether that means extending, pausing, or reducing doses to manage nausea based on your symptoms and overall progress

The pharmacologic effects of GLP-1 are noted in the next figure

Put them together and the triple combo might achieve the best of all worlds: You get a reduction in food intake, and you can turn the dial up and get a little better energy expenditure, Jonathan Campbell, an obesity researcher at Duke, told me

These effects are statistically significant but clinically modest

It's important to remain vigilant for symptoms throughout your time on the medication

Below is a breakdown of some of the most common side effects from a study that directly compared Wegovy (semaglutide) and Zepbound (tirzepatide)