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Besides obesity, dysregulation of TNF production has been implicated in a variety of human diseases, including Alzheimers disease (91), cancer (92), rheumatoid arthritis (74), and IBD (93)

Modifications of position 12 in a parathyroid hormone and parathyroid hormone-related protein: toward the design of highly potent antagonists

Other important safety considerations include injection site reactions, increased heart rate (a class effect, though potentially more pronounced with liraglutide), and risk of pancreatitis (which requires immediate discontinuation if suspected)

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These non-incretin metabolic peptides frequently exert effects on peripheral tissues such as skeletal muscle, adipose tissue, liver, and vasculature, and often engage receptors distinct from those targeted by current therapies

Amplification of exocytosis by Ca2+-induced Ca2+ release in INS-1 pancreatic beta cells