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While these features are associated with a LoF phenotype, other studies suggest that both GIPR agonists and antagonists may provide benefits to T2D and obesity (Yang et al., 2022), indicating a complex mechanism of GIPR action within the processes of blood glucose and weight regulation

Fatigue typically improves as the body becomes more efficient at using fat for energy

Water weight typically sheds quickly, and the scale often drops noticeably within a few days

B-vitamins, particularly vitamin B12 , play an essential role in energy production and metabolism

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Those in the higher dose group were also significantly more likely to reach weight reductions of up to 20% of their waist circumference (a clinically meaningful measure of cardiometabolic risk) and improve their HbA1C (a measure of blood sugar control) compared with the other two groups