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El-Jamal N, Erdual E, Neunlist M, Koriche D, Dubuquoy C, Maggiotto F, et al

This discrepancy may arise from tirzepatides unique dual GLP-1 and GIP receptor agonist mechanism and lower GLP-1 receptor affinity, affecting ocular vascular and metabolic responses differently than semaglutide, the authors explained in their AJO report

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Variants in the GLP1R gene (rs6923761) affect receptor sensitivity, meaning some patients achieve weight loss at lower doses while others require higher onesyet the cost remains constant with PlexusDx's flat-rate pricing model