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Pre-treatment with a GLP1 receptor-blocking antibody neutralised the CNO-dependent improvement in glucose tolerance but did not affect the reduction in food intake, and an independent group of animals pair-fed to the CNO-treatment group demonstrated attenuated weight loss

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Methods A comprehensive literature review was conducted, including evidence from case reports, randomized controlled trials, prospective cohorts, and experimental studies, to assess the role of GLP-1RAs in psoriasis treatment

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Tirzepatide (TZP), a dual GLP-1/GIP receptor agonist, is recognized for its potent glycemic and weight-lowering effects, yet its influence on hepatic mitochondrial dynamics in diabetes remains unclear