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Even intravenous administration of GLP-1 at a physiological postprandial dose of 0.3 pmol/kg/min significantly slowed the rate of gastric emptying in healthy subjects, bringing them into a state of gastroparesis (Little et al., 2006)

Semaglutide is an FDA-approved GLP-1 medication that helps regulate appetite, reduce cravings, and improve fullness signals

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C57BL/6J mice performed sham operation fed with normal diet were used as control group