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All animal experiments followed protocols approved by The Scripps Research Institute IACUC (protocol 09-0111), Johannes Gutenberg University Medical Centre Mainz (Landesuntersuchungsamt Koblenz, AZ 23-177-07/G14-1-55 and G 19-1-063), or the Institutional Animal Research Committee of Tongji Medical College (IACUC no

A 2025 paper in the journal Endocrine put it plainly: the facial aging effect is not exclusively related to decreased facial fat. Additional mechanisms have yet to be identified

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