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The strategy was then applied to semaglutide, a FDA approved GLP-1 analogue, to generate hybrid 24 and we showed that not only the in vivo activity was preserved, but the stability toward pancreatin was improved opening the way for improvement in oral administration

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[DOI] [PubMed] [Google Scholar] 3.Krhus ML, Ellegaard AM, Winther-Jensen M, et al

Incretin-based therapies and acute pancreatitis risk: a systematic review and meta-analysis of observational studies

GLP-1 stimulates cell proliferation in pancreatic ductal cells and islets, and exerts antiapoptotic actions on islet -cells and neurons
