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A review in Diabetes Technology & Therapeutics concluded that while some studies showed small benefits, results were inconsistent across trials

To investigate the physiological functions of endogenous GLP-1 mediated via vagal sensory neurons, a rat model with vagal sensory neuron-specific GLP-1R knockdown was generated by microinjecting a viral vector expressing GLP-1R shRNA into the nodose ganglion [51]

[13] A 2021 meta-analysis found that over 1 year of clinical use, tirzepatide was superior to dulaglutide, semaglutide, insulin degludec, and insulin glargine in improving blood sugar control and reducing body weight

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Its easy to celebrate your success by loosening the reins, but consistency is key for maintenance

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