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The PubMed search strategy used was: ((Insulin Resistance[MeSH Terms] OR Metabolic Syndrome[MeSH Terms] OR Glucose Intolerance[MeSH Terms] OR Prediabetic State[MeSH Terms] OR Insulin Resistance[Title/Abstract] OR Metabolic Syndrome[Title/Abstract] OR Glucose Intolerance[Title/Abstract] OR prediabetes[Title/Abstract]) AND (Akkermansia[Title/Abstract] OR Akkermansia muciniphila[Title/Abstract] OR a muciniphila[Title/Abstract] OR muciniphila[Title/Abstract])) AND ((ffrft[Filter]) AND (fft[Filter]) AND (english[Filter])) In addition to PubMed, Europe PMC was utilized to increase search sensitivity by identifying relevant full-text articles, preprints, and research outputs supported by European funding agencies, ensuring broader international coverage of the available evidence

World J Diabetes 2014;5:901-4.ArticlePubMedPMC 56

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C-reactive protein, its role in inflammation, Type 2 diabetes and cardiovascular disease, and the effects of insulin-sensitizing treatment with thiazolidinediones

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One study demonstrated that exendin-4 (50 nM) treatment reduces the expression of pro-inflammatory genes such as NF-B p65 and the TNF receptor superfamily member 1A in human pancreatic islet cells (Velmurugan et al., 2012)