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N Engl J Med 384:11131124 Sanyal AJ, Newsome PN, Kliers I et al (2025) Phase 3 trial of semaglutide in metabolic dysfunction-associated steatohepatitis

And that question requires looking beyond the marketing claims and into the actual science of GLP-1 related nutrient depletion

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Patients who push through the first 8 weeks almost always find the medication progressively easier to tolerate

Glucose-dependent insulinotropic polypeptide may enhance fatty acid re-esterification in subcutaneous abdominal adipose tissue in lean humans