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While this specific trial evaluated semaglutide rather than retatrutide, the findings provide critical context for evaluating the cardiovascular risk-benefit profile of incretin-based therapies

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doi:10.1056/NEJMoa1603827 Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR, et al

There is also a caution regarding diabetic retinopathy, particularly in patients using insulin