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-cell apoptosis is mediated by a series of cascade mechanisms of the cysteine protease family, and current studies on hyperglycemia-induced -cell apoptosis have focused on the balance between the pro-apoptotic Bcl-2 proteins (Bad, Bid, Bik, and Bax) and the anti-apoptotic Bcl family (Bcl-2 and Bcl-xl) (Tomita, 2016), and apoptosis occurs only when the concentration of the pro-apoptotic protein Bcl-2 on the mitochondrial membrane of the intrinsic pathway exceeds the concentration of the anti-apoptotic protein
Intermittent fasting in type 2 diabetes mellitus and the risk of hypoglycaemia: a randomized controlled trial
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El componente de glucagon, el tercer pilar, eleva el gasto energetico en reposo al estimular la lipolisis hepatica y producir efectos termogenicos
