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Shapsis calls it a metabolic breakthrough.

The gut microbiome is considered the most abundant pool of microorganisms, which release metabolic products that facilitate gut-brain signaling

In conclusion, the paper provides evidence that the reduction of GLP-1+ cells is a general feature of ileal and colonic inflammation in mice and humans and is likely due to altered epithelial differentiation driven by changes in cellular metabolism, particularly mitochondrial dysfunction.

Weight management with GLP-1 drugs supports weight loss and improves metabolic health, reducing risks of type 2 diabetes and heart disease.

Maintaining a balanced diet rich in fiber, lean proteins, and essential nutrients is important

When patients on GLP-1 therapy also make healthy lifestyle choicesgetting enough sleep and exercising, for examplethe benefits are significantly greater.